FRONTLINE Combo® Spot-on for dogs XL over 40kg - against fleas and ticks

Product information & legal requirements

FRONTLINE COMBO® is a veterinary medicinal product for the protection of dogs against fleas, ticks, and biting lice. The combination of fipronil and (S)-methoprene combats adult parasites while simultaneously inhibiting the development of flea eggs, larvae, and pupae.

Intended use

This version of FRONTLINE COMBO® containing 402 mg of fipronil and 361.8 mg of (S)-methoprene is intended for dogs with a body weight of over 40 kg.

The spot-on is used for flea infestations alone or in combination with tick and/or biting lice infestations.

Properties and effect

FRONTLINE COMBO® combines two active ingredients:

• Fipronil is effective against fleas, ticks, and biting lice.

• (S)-Methoprene acts as an insect growth regulator to inhibit the development of flea eggs, larvae, and pupae.

Key properties:

• Protection against fleas, ticks, and biting lice

• Effective against adult fleas for up to 8 weeks

• Effective against ticks for up to 4 weeks

• Inhibits the development of immature flea stages

• Supports the control of flea infestations in the home environment

• Easy spot-on application

• Also suitable for pregnant and lactating bitches

Why is it important to control immature flea stages?

Adult fleas on the dog represent only a small part of the total flea population. Eggs, larvae, and pupae can be found in the animal's environment and cause a re-infestation.

(S)-methoprene inhibits the development of these immature flea stages, thereby supplementing the effect of fipronil against adult parasites.

How quickly does FRONTLINE COMBO® work?

Fleas are killed within 24 hours, and ticks and biting lice within 48 hours.

After application, the active ingredient spreads over the dog's skin surface within approximately 1 to 2 days.

Application

FRONTLINE COMBO® is applied as a spot-on directly to the skin:

1. Take the pipette out of the packaging and hold it upright.

2. Tap lightly to ensure the liquid collects in the main body.

3. Snap off the tip of the pipette at the designated spot.

4. Part the fur between the shoulder blades until the skin is visible.

5. Place the tip of the pipette directly onto the skin and empty the entire contents.

Temporary clumping or a greasy appearance of the hair may occur at the application site. These changes usually disappear again.

How often to apply?

FRONTLINE COMBO® protects against fleas and their immature developmental stages for up to 8 weeks. The effect against ticks lasts for up to 4 weeks.

There should be an interval of at least 4 weeks between two applications.

Notes on application and environment

Intensive bathing should be avoided within 48 hours before or after treatment. FRONTLINE® products are water-resistant 48 hours after application.

In the event of a flea infestation, all appropriate dogs and cats in the household should be treated accordingly. In addition, the environment should be cleaned regularly. Thorough vacuuming and washing of suitable textiles, blankets, and toys at at least 60 °C can support flea control.

Important information

FRONTLINE COMBO® Spot-on for dogs is available in different dosages depending on body weight:

• S: Dogs over 2 to 10 kg

• M: Dogs over 10 to 20 kg

• L: Dogs over 20 to 40 kg

• XL: Dogs over 40 kg

This version with 402 mg fipronil and 361.8 mg (S)-methoprene is intended for dogs over 40 kg.

This product is a veterinary medicinal product. For information regarding use, potential side effects, and adverse reactions, please read the package leaflet or consult your veterinarian or pharmacist.

RCV-PHC-0064-2021

Ingredients

Active ingredients:

• 402 mg Fipronil

• 361.8 mg (S)-Methoprene

Excipients:

• Ethanol

• Polysorbate 80

• 0.8 mg Butylhydroxyanisole

• 0.4 mg Butylhydroxytoluene

• Povidone

• Diethylene glycol monoethyl ether

Side effects and tolerance

Like all veterinary medicinal products, FRONTLINE COMBO® can cause side effects.

Temporary changes to the coat, such as matted or greasy hair, may occur at the application site.

In the event of unusual reactions or complaints, refer to the package leaflet and consult your veterinarian or pharmacist if necessary.