FRONTLINE COMBO® Spot-on for fleas and ticks Dog XL over 40kg

FRONTLINE COMBO® for Dogs

FRONTLINE COMBO® offers protection against fleas, ticks and biting lice and has a sustainable effect against fleas. It kills fleas and at the same time inhibits the development of eggs, larvae and pupae, thereby also protecting the household environment from flea infestation.
All advantages at a glance:

• Protection against fleas, ticks and biting lice
• Long-lasting protection against fleas
• Inhibits the development of flea eggs, larvae and pupae
• Protects the household environment from flea infestation
• The effect against adult fleas lasts up to 8 weeks in dogs
• Easy to use
• Can be used on dogs from 8 weeks of age or weighing at least 2 kg
• Also suitable for pregnant and lactating bitches.
• Now available without a prescription
• Available without a prescription at the pharmacy from 2022

Why is it important to protect your dog from fleas?
Fleas are active all year round and can be brought into the home by pets. A brief encounter with other animals or wildlife such as hedgehogs can be enough to bring a flea infestation with various disease risks into the home. A flea treatment usually lasts 2-4 months.

• Visible adult fleas on the animal account for only about 5% of the total flea population.
• The majority of the population (eggs, larvae, pupae) spreads almost invisibly and very quickly in the living area.
• A flea can lay 30-50 eggs daily, which fall from the fur into the animal's environment. From these, larvae hatch, which molt several times and pupate until adult fleas finally hatch. This cycle takes about 3-4 weeks.
• So, if you find 10 fleas, that means 300-500 eggs daily. A plague can quickly develop.

How FRONTLINE COMBO® works:
The effect of FRONTLINE COMBO® is based on the combination of the active ingredients fipronil and (S)-methoprene.
Fipronil affects the nerve conduction of insects (such as fleas and biting lice) and arachnids (such as ticks), leading to the death of the parasites. The active ingredient works in invertebrates, but not in mammals such as cats, dogs or humans. (S)-Methoprene is an insect growth regulator (IGR) that inhibits the development of immature stages of insects. (S)-Methoprene penetrates the eggshell of freshly laid flea eggs or is absorbed by adult fleas through the cuticle. In addition, the development of larvae and pupae is disrupted, which can free the environment of the treated animal from these stages.

How quickly does FRONTLINE COMBO® take effect?
Fleas are killed within 24 hours just 2 days after application, while ticks and biting lice are killed within 48 hours.

Application:
FRONTLINE COMBO® is a spot-on and particularly easy to apply:

• Take a pipette from the packaging.
• Hold the pipette tip upright.
• Tap gently so that the liquid collects completely in the main part of the pipette.
• Break off the tip of the pipette at the perforated point.
• Part the animal's fur in the neck area until the skin is visible.
• Place the pipette tip directly on the skin and empty the entire contents onto the skin.

The active ingredient spreads within 1-2 days from the spot between the shoulder blades, inaccessible to the animal, across the entire skin surface. Temporary changes in the fur (matted/greasy hair) may occur at the application site, but these will disappear.

How often should FRONTLINE COMBO® be used on your dog?

To ensure continuous effectiveness, a sufficient amount of active ingredient must be present. Therefore, the product should be used regularly. Parasites are active all year round – fleas are not only a problem in summer and autumn, but also thrive in heated rooms in winter. We therefore recommend year-round prophylactic treatment, especially for indoor pets.
FRONTLINE COMBO® protects your dog for 8 weeks from fleas and their immature stages (eggs, larvae, pupae). The effect against ticks lasts 4 weeks. The recommended interval between two applications should be at least 4 weeks.

Notes:

• Intensive bathing before or after application (within 48 hours) should be avoided, as this can impair the distribution of the active ingredient. From 48 hours after application, FRONTLINE® products are waterproof.
• It is also important that all cats and dogs living in the household are treated regularly and simultaneously. Untreated cats or dogs can repeatedly re-infest other animals, especially in the case of flea infestation.
• In the event of a flea infestation, the environment must also be freed of fleas. Otherwise, the animal can be re-infested again and again. It should be vacuumed daily and thoroughly (even in corners and edges), textiles, bedding, toys, etc. should be washed at a minimum of 60 degrees, and additional products for environmental treatment should be used.

Legal notice:
Frontline Combo Spot on Dog S//M//L///XL, cutaneous solution, for dogs.
Active ingredients: Fipronil, (S)-Methoprene. Indications: For the treatment of dogs weighing over 2 to 10 kg// over 10 to 20 kg// over 20 to 40 kg// over 40 kg: against flea infestations, alone or in combination with tick and/or biting lice infestations. The product is a veterinary medicinal product. For information on use, possible side effects and undesirable effects, please read the package leaflet or consult your veterinarian or pharmacist. RCV-PHC-0064-2021