FRONTLINE COMBO® Spot-on against fleas and ticks for dogs S 2-10kg

FRONTLINE COMBO® for Dogs

FRONTLINE COMBO® offers protection against fleas, ticks and biting lice and has a particularly long-lasting effect against fleas. FRONTLINE COMBO® kills fleas and simultaneously inhibits the development of flea eggs, larvae and pupae. This also protects the household environment from flea infestation.
All benefits at a glance:

• Protection against fleas, ticks and biting lice
• Long-lasting protection against fleas
• Inhibits the development of flea eggs, larvae and pupae
• Protects the household environment from flea infestation
• The effect against adult fleas lasts up to 8 weeks in dogs
• Easy to use
• Can be used in dogs from 8 weeks of age or 2 kg
• Also suitable for pregnant and lactating bitches.
• Now available without prescription
• Available without prescription in pharmacies from 2022

Why should you particularly protect your dog from fleas?
Fleas are active all year round and are picked up by pets in nature. A brief encounter with other animals or wild animals such as hedgehogs is enough to bring a flea infestation, associated with various health risks, into your home. Treating a flea infestation usually takes 2-4 months.

• Adult fleas visible on the animal make up only 5% of the total flea population.
• The rest of the population (eggs, larvae, pupae) spreads almost invisibly and rapidly in the home environment.
• A flea can lay 30-50 eggs daily – these fall from the coat into the animal's environment. Larvae hatch from these, which moult several times and pupate until adult fleas finally hatch. This cycle takes approx. 3-4 weeks.
• So, if you find 10 fleas – that means 300-500 eggs per day. This quickly leads to an infestation.

How FRONTLINE COMBO® works:
The effect of FRONTLINE COMBO® is based on the combination of the active ingredients Fipronil and (S)-Methoprene.
Fipronil disrupts the nerve conduction of insects (e.g., fleas and biting lice) and arachnids (e.g., ticks), causing the parasites to die. The active ingredient works on invertebrates, but not on mammals such as cats, dogs, or humans. (S)-Methoprene is an insect growth regulator (IGR) that inhibits the development of immature stages of insects. (S)-Methoprene penetrates the eggshell of freshly laid flea eggs or is absorbed through the cuticle of adult fleas. In addition, the development of larvae and pupae is disrupted, so that the environment of the treated animal can be kept free of these stages.

How quickly does FRONTLINE COMBO® take effect?
Starting 2 days after treatment, fleas are killed within 24 hours and ticks and biting lice within 48 hours.

Application:
FRONTLINE COMBO® is a spot-on and particularly easy to use:

• Remove one pipette from the box.
• Hold the pipette tip upright.
• Tap lightly so that the liquid completely collects in the main part of the pipette.
• Break off the tip of the pipette at the perforated section.
• Part the animal's fur in the neck region until the skin is visible.
• Place the pipette tip directly on the skin and completely empty the liquid contents onto the skin.

From the area between the shoulder blades, which is inaccessible to the animal, the active ingredient spreads over the entire skin surface within 1-2 days. Temporary changes in fur (matted/greasy hair) may occur at the application site - these will disappear again.

How often should FRONTLINE COMBO® be used on your dog?

To ensure an effect without a protection gap, there must always be sufficient active ingredient. Therefore, the product should be used regularly. Parasites are active all year round - for example, fleas are not only an issue in summer and autumn - they also feel very comfortable in heated homes in winter. We therefore recommend treating indoor animals preventively all year round.
FRONTLINE COMBO® protects your dog for 8 weeks against fleas and their immature stages (eggs, larvae, pupae). The effect against ticks lasts for 4 weeks. The recommended interval between two treatments should be at least 4 weeks.

Notes:

• Intensive bathing before or after treatment (within 48 hours) should be avoided, as this can impair the distribution of the active ingredient. Starting 48 hours after treatment, FRONTLINE® products are waterproof.
• It is also important that all cats and dogs living in the household are treated regularly and simultaneously. Untreated cats or dogs can - especially in the case of flea infestation - repeatedly infect the others.
• In the event of a flea infestation, the environment must also be freed from fleas. Otherwise, the animal can be re-infested repeatedly. You should vacuum daily and very thoroughly (including corners and edges), wash textiles, blankets, toys, etc. at a minimum of 60 degrees, and also use products for environmental treatment.

Mandatory text:
Frontline Combo Spot on Dog S//M//L///XL, solution for topical application to the skin, for dogs
Active ingredients: Fipronil, (S)-Methoprene. Indications: For the treatment of dogs with a body weight of over 2 to 10 kg// over 10 to 20 kg// over 20 to 40 kg// over 40 kg: against flea infestation, alone or in combination with tick and/or biting louse infestation. The product is a veterinary medicinal product. For information on use, potential side effects, and undesirable effects, please read the package insert or consult your veterinarian or pharmacist. RCV-PHC-0064-2021