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Myrkkysumakilla on pitkä historia perinteisessä käytössä, erityisesti alkuperäiskansoilla, jotka käyttivät sen lehtiä ja kuorta erilaisissa sovelluksissa.\u003c\/p\u003e\u003cp\u003eHomeopatiassa \u003cstrong\u003eToxicodendron quercifolium\u003c\/strong\u003e-valmistetta käytetään perinteisesti lievittämään oireita, jotka liittyvät ihoreaktioihin ja allergisiin reaktioihin. Sen uskotaan voivan olla hyödyllinen hoidettaessa vaivoja, jotka aiheutuvat kasvin kanssa kosketuksiin joutumisesta. 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